Cardiac Action Potential Prolongation Induced by Isolated Thioridazine Enantiomers
نویسنده
چکیده
منابع مشابه
Mechanistic approach for thioridazine-induced hepatotoxicity and potential benefits of melatonin and/or coenzyme Q10 on freshly isolated rat hepatocytes
Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...
متن کاملMechanistic approach for thioridazine-induced hepatotoxicity and potential benefits of melatonin and/or coenzyme Q10 on freshly isolated rat hepatocytes
Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...
متن کاملPro-Arrhythmic Effects of Noncardiac Medications: Lessons From Macrolide Antibiotics.
S udden death resulting from medications prescribed with good intentions is an everpresent threat first recognized nearly a century ago (1,2). As early as 1923, when quinidine was first used as antiarrhythmic therapy, a disturbing phenomenon was noted: some patients treated with quinidine suffered from sudden collapses, sometimes ending in unexpected deaths (2). These events were first attribut...
متن کاملPsychotropic Medications, Associated QTc Prolongation, and Sudden Cardiac Death: A Review for Clinicians
Prolongation of QTC is an electrocardiographic finding indicating prolongation of cardiac repolarization, which increases the risk for torsades de pointes, a form of ventricular tachycardia that can lead to sudden cardiac death. Sudden cardiac death in the setting of antipsychotic treatment was first described in the 1960s with thioridazine; since that time, many other psychotropic medications ...
متن کاملPsychotropic drugs, cardiac arrhythmia, and sudden death.
A variety of drugs targeted towards the central nervous system are associated with cardiac side effects, some of which are linked with reports of arrhythmia and sudden death. Some psychotropic drugs, particularly tricyclic antidepressants (TCAs) and antipsychotic agents, are correlated with iatrogenic prolongation of the QT interval of the electrocardiogram (ECG). In turn, this is associated wi...
متن کامل